BioScience Trends. 2018;12(4):354-359. (DOI: 10.5582/bst.2018.01078)

Transcriptomic responses of peripheral blood cells to coronary artery disease.

Lin MS, Zhang Y, Niu Z, Chi Y, Huang Q


Transcriptomic response of peripheral blood cells to coronary artery diseases (CAD) is a long recognized phenomenon. Currently, accumulating evidence indicates that such response having significant clinical utility in CAD-associated events determination. In this review, we summarized the existing data of transcriptomic biomarkers at mRNA, microRNA, long non-coding RNA, and circular RNA for the diagnosis, progression and outcome prediction and treatment response of CAD. Furthermore, we also discussed the functional significance on the gene expression patterns caused by CAD, and emphasized the importance of inflammatory pathways in CAD tissues-blood cells interaction. Based on the current knowledge, we proposed a perspective on the future strategies to further improve the robustness and reproducibility of transcriptomic biomarkers in the personalized medicine of CAD patients.

KEYWORDS: Coronary artery diseases, transcriptome, biomarkers, peripheral blood cells, non-coding RNA

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