BioScience Trends. 2020;14(3):209-211. (DOI: 10.5582/bst.2020.03154)

Does immune privilege result in recovered patients testing positive for COVID-19 again?

Xia J


Recently, an increasing number of reports have indicated that a few patients who were believed to have recovered from COVID-19 initially tested negative but later tested positive. Several hospitals in different countries have detected SARS-CoV-2 RNA in the semen and cerebrospinal fluid of patients with severe COVID-19. Given the fact that the testes and central nervous system are both immune privilege sites and the fact that Ebola virus and Zika virus can avoid immune clearance and continue proliferating and spreading by hiding in those sites, the question of whether SARS-CoV-2 is present in immune privilege sites, it attacks those sites, and it spreads again after proliferating in those sites needs to be investigated.

KEYWORDS: SARS-CoV-2, COVID-19, immune privilege, re-detectable positive, semen, CNS

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