BioScience Trends. 2021;15(1):58-60. (DOI: 10.5582/bst.2020.03429)

Zbtb7a and Zbtb7b: Opening naïve loci to reprogram ESCs

Cao H, Huang H, Tang HF


Bone morphogenetic protein 4 (BMP4) was recently reported to confer reprogramming capability to embryonic stem cells (ESCs) by reactivating naïve pluripotency genes via Zbtb7a and Zbtb7b. A visual reporting system was developed to first identify BMP4 as a driver for the primed-to-naïve transition (PNT). In addition, two specific inhibitors were identified as significantly improving the efficiency of PNT (~80% transition) within 8 days. The Zbtb7 family members were first introduced in the context of PNT and stem cell fate decision-making. These findings provide valuable information on acquiring naïve pluripotent stem cells for regenerative medicine.

KEYWORDS: BMP4, fate decision-making, PNT, reprogramming

Full Text: