BioScience Trends. 2026;20(3):332-339. (DOI: 10.5582/bst.2026.01141)

Imported Ebola as a stress test of hospital resilience in an era of global connectivity

Ma Y, Xu YF, Tan L, Tian YM, Ran JC, Zeng XH, Huang T, Lu HZ

In May 2026, an outbreak of Ebola virus disease caused by Bundibugyo ebolavirus emerged in the Democratic Republic of the Congo and spread to Uganda, prompting a WHO Public Health Emergency of International Concern. With no approved vaccine or specific antiviral treatment, Bundibugyo virus poses an acute importation risk in an era of dense global air travel. This perspective frames imported Ebola as a hospital resilience stress test and proposes the Hospital Resilience 4P Framework, organizing preparedness around Prediction, Preparedness, Protection, and Partnership. We critically analyze the drivers of nosocomial amplification, including diagnostic delay, healthcare worker undertraining, and insufficient infection prevention and control. For China, whose aviation hubs in Guangzhou and Shenzhen sustain dense air links with Africa under the Belt and Road Initiative, this risk is particularly urgent. We further examine the vulnerabilities of East Asian healthcare systems - aging workforces, emergency department overcrowding, and skewed PPE stockpiles - and evaluate emerging technologies (deep-ultraviolet laser disinfection, AI-driven surveillance, differential serology) with explicit evidence grading. A full-chain, multi-layered system from the aircraft cabin to isolation ward, guided by the 4P Framework, can ensure imported cases remain contained clinical events rather than triggers of hospital-based outbreaks.

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