BioScience Trends. 2012;6(1):33-37. (DOI: 10.5582/bst.2012.v6.1.33)

Ageing in Werner syndrome.

Goto M, Iwaki-Egawa S, Watanabe Y


Oxidative stress markers including pentosidine and homocysteine were examined comparing them with inflammation markers including highly sensitive C-reactive protein (hsCRP) and matrix metalloproteinase-9 (MMP-9) in serum from patients with Werner syndrome (WS) and healthy individuals. Elevation of serum pentosidine correlated significantly with normal aging in healthy individuals (p < 0.0004). Serum pentosidine in WS increased significantly compared with age-matched healthy individuals (p < 0.05). Serum homocysteine levels increased insignificantly with normal aging in healthy individuals and in WS compared with age-matched healthy individuals. As both pentosidine and homocysteine levels did not correlate with hsCRP or MMP-9, both oxidative stress markers may be differentially regulated by inflammation.

KEYWORDS: Aging, homocysteine, inflammation, oxidative stress, pentosidine, C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9)

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